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Adding to what Le Boule already stated, I doubt your problem has anything to do with Windows Defender, since you indicated the problems started after the installation of last week's Windows Updates.
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Though it's possible one of these updates was for Windows Defender, unless you are specifically receiving a notification from Defender itself it's much more likely that one of the other Windows updates is causing your application to fail.
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The way to determine this is to disable Windows Automatic Update for now and temporarily change it to one of the other settings that allows you to decide whether to install the specific updates. Then you can selectively install each update one at a time until you find the one which causes the application to fail.
At that point you can either take that information to Peachtree support, Microsoft Support or post for additional help on their forums to discuss why that specific update might cause this. At this moment you really have no idea what's causing your problem other than it started with some Windows updates, which is basically useless information.
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Rob